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HelpTest Code PMHPU Pain Management Hybrid Profile, 22 Drug Classes, High-Resolution Mass Spectrometry and Immunoassay Screen, Random, Urine
Ordering Guidance
This test does not screen for drug classes other than those listed in Reference Values.
Specimen Required
Supplies: Urine Container, 60 mL (T313)
Collection Container/Tube: Plastic urine container
Submission Container/Tube: Plastic, 60-mL urine container
Specimen Volume: 30 mL
Collection Instructions:
1. Collect a random urine specimen.
2. Submit 30 mL in 1 plastic bottle.
3. No preservative.
Additional Information:
1. No specimen substitutions.
2. Submitting less than 30 mL may compromise the ability to perform all necessary testing.
3. STAT requests are not accepted for this test.
Useful For
Detecting drug use involving stimulants, barbiturate, benzodiazepines, cocaine, opioids, tetrahydrocannabinol, gabapentinoids, and alcohol.
Clinical monitoring or management of patients
This test is not intended for use in employment-related testing.
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| LPCM | List Patient's Current Medications | No | Yes |
| ADULT | Adulterants Survey, U | Yes | Yes |
| LDPU | Limited Drug Panel, 3, IA, U | No | Yes |
| TOPU | Targeted Opioid MS Screen, U | Yes, (Order TOSU) | Yes |
| TABSU | Targeted Benzodiazepine Screen, U | Yes, (Order TBSU) | Yes |
| TSIM | Gabapentinoid/Stim MS Screen, U | Yes, (Order TGSU) | Yes |
| ETGSR | Ethyl Glucuronide Scrn w/Reflex, U | No | Yes |
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| ETGC | Ethyl Glucuronide Confirmation, U | Yes | No |
Testing Algorithm
Testing begins with an adulterant survey. If the sample is found to be adulterated, testing will end and the remaining tests will be canceled.
If the specimen is normal or only diluted, remaining testing will continue.
Positive results can be confirmed and quantitated by definitive methods: gas chromatography mass spectrometry for barbiturates, cocaine and metabolites and liquid chromatography tandem mass spectrometry for tetrahydrocannabinol metabolites. Ethyl glucuronide/ethyl sulfate confirmation will be performed at an additional charge.
Special Instructions
Method Name
ADULT: Spectrophotometry (SP)
ETGSR, LDPU: Immunoassay
TABSU, TOPU, TSIM: Liquid Chromatography Tandem Mass Spectrometry, High-Resolution Accurate Mass (LC-MS/MS HRAM)
Reporting Name
Pain Mgt Profile, 22, HRMS/IA, USpecimen Type
UrineSpecimen Minimum Volume
20 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Urine | Refrigerated (preferred) | 14 days |
| Frozen | 14 days |
Reject Due To
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.Reference Values
ADULTERANT SURVEY:
Cutoff concentrations
Oxidants: 200 mg/L
Nitrites: 500 mg/L
LIMITED DRUG PROFILE, 3 DRUG CLASSES, IMMUNOASSAY PANEL:
Negative
Screening cutoff concentrations:
Barbiturates: 200 ng/mL
Cocaine (benzoylecgonine-cocaine metabolite): 150 ng/mL
Tetrahydrocannabinol carboxylic acid: 50 ng/mL
TARGETED OPIOID MASS SPECTROMETRY SCREEN:
Not detected (Positive results are reported with qualitative "Present" results)
Cutoff concentrations:
Codeine: 25 ng/mL
Codeine-6-beta-glucuronide: 100 ng/mL
Morphine: 25 ng/mL
Morphine-6-beta-glucuronide: 100 ng/mL
6-Monoacetylmorphine: 25 ng/mL
Hydrocodone: 25 ng/mL
Norhydrocodone: 25 ng/mL
Dihydrocodeine: 25 ng/mL
Hydromorphone: 25 ng/mL
Hydromorphone-3-beta-glucuronide: 100 ng/mL
Oxycodone: 25 ng/mL
Noroxycodone: 25 ng/mL
Oxymorphone: 25 ng/mL
Oxymorphone-3-beta-glucuronide: 100 ng/mL
Noroxymorphone: 25 ng/mL
Fentanyl: 2 ng/mL
Norfentanyl: 2 ng/mL
Meperidine: 25 ng/mL
Normeperidine: 25 ng/mL
Naloxone: 25 ng/mL
Naloxone-3-beta-glucuronide: 100 ng/mL
Methadone: 25 ng/mL
2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP): 25 ng/mL
Tramadol: 25 ng/mL
O-desmethyltramadol: 25 ng/mL
Tapentadol: 25 ng/mL
N-desmethyltapentadol: 50 ng/mL
Tapentadol-beta-glucuronide: 100 ng/mL
Buprenorphine: 5 ng/mL
Norbuprenorphine: 5 ng/mL
Norbuprenorphine glucuronide: 20 ng/mL
TARGETED BENZODIAZEPINE MASS SPECTROMETRY SCREEN:
Not detected (Positive results are reported with qualitative "Present" results)
Cutoff concentrations:
Alprazolam: 10 ng/mL
Alpha-hydroxyalprazolam: 10 ng/mL
Alpha-hydroxyalprazolam glucuronide: 50 ng/mL
Chlordiazepoxide: 10 ng/mL
Clobazam: 10 ng/mL
N-desmethylclobazam: 200 ng/mL
Clonazepam: 10 ng/mL
7-Aminoclonazepam: 10 ng/mL
Diazepam: 10 ng/mL
Nordiazepam: 10 ng/mL
Flunitrazepam: 10 ng/mL
7-Aminoflunitrazepam: 10 ng/mL
Flurazepam: 10 ng/mL
2-Hydroxy ethyl flurazepam: 10 ng/mL
Lorazepam: 10 ng/mL
Lorazepam glucuronide: 50 ng/mL
Midazolam: 10 ng/mL
Alpha-hydroxymidazolam: 10 ng/mL
Oxazepam: 10 ng/mL
Oxazepam glucuronide: 50 ng/mL
Prazepam: 10 ng/mL
Temazepam: 10 ng/mL
Temazepam glucuronide: 50 ng/mL
Triazolam: 10 ng/mL
Alpha-hydroxytriazolam: 10 ng/mL
Zolpidem: 10 ng/mL
Zolpidem phenyl-4-carboxylic acid: 10 ng/mL
TARGETED GABAPENTINOID AND STIMULANT MASS SPECTROMETRY SCREEN:
Not detected (Positive results are reported with qualitative "Present" results)
Cutoff concentrations:
Methamphetamine: 100 ng/mL
Amphetamine: 100 ng/mL
3,4-Methylenedioxymethamphetamine (MDMA): 100 ng/mL
3,4-Methylenedioxy-N-ethylamphetamine (MDEA): 100 ng/mL
3,4-Methylenedioxyamphetamine (MDA): 100 ng/mL
Ephedrine: 100 ng/mL
Pseudoephedrine: 100 ng/mL
Phentermine: 100 ng/mL
Phencyclidine (PCP): 20 ng/mL
Methylphenidate: 20 ng/mL
Ritalinic acid: 100 ng/mL
Gabapentin: 500 ng/mL
Pregabalin: 500 ng/mL
ETHYL GLUCURONIDE SCREEN:
Negative
Screening cutoff concentrations:
Ethyl glucuronide: 500 ng/mL
Day(s) Performed
Monday through Saturday
Report Available
3 to 4 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
G0482
80307
80364 (if appropriate for select payers)
80347 (if appropriate for select payers)
80326 (if appropriate for select payers)
80321 (if appropriate for select payers)
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| PMHPU | Pain Mgt Profile, 22, HRMS/IA, U | 69739-1 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| LPCM | List Patient's Current Medications | 66423-5 |
| 615289 | Barbiturates | 19270-8 |
| 20606 | Creatinine, U | 2161-8 |
| 616033 | Ethyl Glucuronide Screen, U | 58375-7 |
| 624198 | Methamphetamine | 19554-5 |
| 604871 | Alprazolam | 94116-1 |
| 624213 | Codeine | 19411-8 |
| 624214 | Codeine-6-beta-glucuronide | 89310-7 |
| 604867 | Alpha-Hydroxyalprazolam | 19325-0 |
| 624199 | Amphetamine | 19343-3 |
| 22312 | Specific Gravity | 5810-7 |
| 615290 | Cocaine | 19359-9 |
| 615291 | Tetrahydrocannabinol | 19415-9 |
| 23509 | pH | 2756-5 |
| 624200 | 3,4-methylenedioxymethamphetamine (MDMA) | 19568-5 |
| 604891 | Alpha-Hydroxyalprazolam Glucuronide | 94115-3 |
| 624215 | Morphine | 19597-4 |
| 624216 | Morphine-6-beta-glucuronide | 89308-1 |
| 604872 | Chlordiazepoxide | 19385-4 |
| 624201 | 3,4-methylenedioxy-N-ethylamphetamine (MDEA) | 59844-1 |
| 23511 | Oxidants | 58714-7 |
| 23510 | Nitrites | 32710-6 |
| 624202 | 3,4-methylenedioxyamphetamine (MDA) | 19565-1 |
| 604889 | Clobazam | 94114-6 |
| 624217 | 6-monoacetylmorphine | 19321-9 |
| 624218 | Hydrocodone | 19482-9 |
| 604890 | N-Desmethylclobazam | 94113-8 |
| 624203 | Ephedrine | 99108-3 |
| 30914 | Comment | 48767-8 |
| 624204 | Pseudoephedrine | 99109-1 |
| 604873 | Clonazepam | 19399-5 |
| 624219 | Norhydrocodone | 89304-0 |
| 624220 | Dihydrocodeine | 19446-4 |
| 604267 | 7-aminoclonazepam | 94112-0 |
| 624205 | Phentermine | 19674-1 |
| 624206 | Phencyclidine (PCP) | 19659-2 |
| 604874 | Diazepam | 19443-1 |
| 624221 | Hydromorphone | 19486-0 |
| 624222 | Hydromorphone-3-beta-glucuronide | 89309-9 |
| 604880 | Nordiazepam | 19624-6 |
| 624207 | Methylphenidate | 19577-6 |
| 624208 | Ritalinic acid | 99110-9 |
| 604875 | Flunitrazepam | 19466-2 |
| 624223 | Oxycodone | 19642-8 |
| 624224 | Noroxycodone | 89303-2 |
| 604866 | 7-aminoflunitrazepam | 94111-2 |
| 624209 | Gabapentin | 68439-9 |
| 624210 | Pregabalin | 105953-4 |
| 604876 | Flurazepam | 19474-6 |
| 624225 | Oxymorphone | 19646-9 |
| 624226 | Oxymorphone-3-beta-glucuronide | 89301-6 |
| 604868 | 2-Hydroxy Ethyl Flurazepam | 94110-4 |
| 624211 | Stimulant Interpretation | 54247-2 |
| 604877 | Lorazepam | 19520-6 |
| 624227 | Noroxymorphone | 89302-4 |
| 624228 | Fentanyl | 59673-4 |
| 604878 | Lorazepam Glucuronide | 94109-6 |
| 604879 | Midazolam | 19585-9 |
| 624229 | Norfentanyl | 43199-9 |
| 624230 | Meperidine | 19532-1 |
| 604869 | Alpha-Hydroxy Midazolam | 94108-8 |
| 604881 | Oxazepam | 19638-6 |
| 624231 | Normeperidine | 27920-8 |
| 624232 | Naloxone | 42618-9 |
| 604882 | Oxazepam Glucuronide | 94107-0 |
| 604883 | Prazepam | 19678-2 |
| 624233 | Naloxone-3-beta-glucuronide | 89307-3 |
| 624234 | Methadone | 19550-3 |
| 604884 | Temazepam | 19698-0 |
| 604885 | Temazepam Glucuronide | 94106-2 |
| 624235 | EDDP | 93495-0 |
| 624236 | Tramadol | 19710-3 |
| 604886 | Triazolam | 19714-5 |
| 604870 | Alpha-Hydroxy Triazolam | 94105-4 |
| 624237 | O-desmethyltramadol | 86453-8 |
| 624238 | Tapentadol | 72485-6 |
| 604887 | Zolpidem | 94104-7 |
| 604888 | Zolpidem Phenyl-4-Carboxylic acid | 94103-9 |
| 624239 | N-desmethyltapentadol | 89306-5 |
| 624240 | Tapentadol-beta-glucuronide | 89300-8 |
| 604949 | Benzodiazepine Interpretation | 69050-3 |
| 624241 | Buprenorphine | 93494-3 |
| 624242 | Norbuprenorphine | 82371-6 |
| 624243 | Norbuprenorphine glucuronide | 89305-7 |
| 624244 | 69050-3 |