Sign in →

Test Code HIAA 5-Hydroxyindoleacetic Acid, 24 Hour, Urine

Reporting Name

5-Hydroxyindoleacetic Acid, U

Useful For

Biochemical diagnosis and monitoring of intestinal carcinoid syndrome using 24-hour urine specimens

Method Name

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Urine


Ordering Guidance


This test is the preferred test for measurement of 5-hydroxyindoleacetic acid concentrations. If a random urine collection is preferred, order HIAAR / 5-Hydroxyindoleacetic Acid, Random, Urine.



Necessary Information


1. Collection duration and urine volume in milliliters are required.

2. Patient's age and sex are required.



Specimen Required


Patient Preparation:

1. Some medications could interfere with test results. The ordering provider should decide if any medications should be stopped and when they should be restarted. If clinically feasible, discontinue the following medications at least 48 hours prior to, as well as during, specimen collection:

-Acetaminophen (Tylenol or generic versions)

-Tryptophan containing supplements

2. For 48 hours prior to, as well as during, the urine collection, the patient should:

Limit the following to one serving per day:

-Fruits

-Vegetables

-Nuts

-Caffeinated beverages or foods

 

Supplies: Urine Tubes, 10 mL (T068)

Container/Tube: Plastic, 10-mL urine tube

Specimen Volume: 5 mL

Collection Instructions:

1. Add 25 mL of 50% acetic acid as preservative at start of collection. Use 15 mL of 50% acetic acid for children <5 years old.

2. Collect a 24-hour urine specimen.

Additional Information: See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens for multiple collections.


Specimen Minimum Volume

1 mL

Reject Due To

  All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 56 days
  Frozen  365 days

Reference Values

 

5-HIAA, mg/24 hour

99th percentile cutoff

Age

Female

Male

≤23 months

≤2.7

≤2.3

24-35 months

≤3.0

≤2.6

3 years

≤3.2

≤2.9

4 years

≤3.4

≤3.2

5 years

≤3.6

≤3.6

6 years

≤3.8

≤3.9

7 years

≤4.0

≤4.2

8 years

≤4.2

≤4.5

9 years

≤4.5

≤4.8

10 years

≤4.7

≤5.1

11 years

≤4.9

≤5.3

12 years

≤5.2

≤5.6

13 years

≤5.4

≤5.8

14 years

≤5.6

≤6.1

15 years

≤5.7

≤6.3

16 years

≤5.9

≤6.4

17 years

≤6.0

≤6.6

18 years

≤6.0

≤6.7

19 years

≤6.1

≤6.8

20 years

≤6.1

≤6.9

21 years

≤6.2

≤6.9

22 years

≤6.2

≤7.0

23 years

≤6.2

≤7.0

24 years

≤6.3

≤7.1

25 years

≤6.3

≤7.2

26 years

≤6.3

≤7.2

27 years

≤6.4

≤7.3

28 years

≤6.4

≤7.4

29 years

≤6.5

≤7.5

30 years

≤6.6

≤7.5

31 years

≤6.6

≤7.6

32 years

≤6.7

≤7.7

33 years

≤6.8

≤7.7

34 years

≤6.8

≤7.8

35 years

≤6.9

≤7.9

36 years

≤6.9

≤7.9

37 years

≤7.0

≤8.0

38 years

≤7.0

≤8.1

39 years

≤7.0

≤8.2

40 years

≤7.1

≤8.2

41 years

≤7.1

≤8.3

42 years

≤7.2

≤8.4

43 years

≤7.3

≤8.5

44 years

≤7.4

≤8.6

45 years

≤7.4

≤8.7

46 years

≤7.5

≤8.8

47 years

≤7.6

≤8.9

48 years

≤7.6

≤9.0

49 years

≤7.7

≤9.1

50 years

≤7.7

≤9.2

51 years

≤7.8

≤9.3

52 years

≤7.8

≤9.4

53 years

≤7.9

≤9.5

54 years

≤8.0

≤9.6

55 years

≤8.1

≤9.7

56 years

≤8.1

≤9.7

57 years

≤8.2

≤9.8

58 years

≤8.3

≤9.8

59 years

≤8.3

≤9.8

60 years

≤8.3

≤9.9

61 years

≤8.3

≤9.9

62 years

≤8.4

≤9.9

63 years

≤8.4

≤10.0

64 years

≤8.4

≤10.0

65 years

≤8.4

≤10.0

66 years

≤8.5

≤10.1

67 years

≤8.5

≤10.1

68 years

≤8.5

≤10.1

69 years

≤8.5

≤10.2

70 years

≤8.5

≤10.2

71 years

≤8.6

≤10.2

72 years

≤8.6

≤10.2

73 years

≤8.5

≤10.1

74 years

≤8.5

≤10.1

75 years

≤8.6

≤10.1

76 years

≤8.6

≤10.0

77 years

≤8.6

≤10.0

78 years

≤8.6

≤10.0

79 years

≤8.6

≤10.0

80 years

≤8.7

≤9.9

81 years

≤8.7

≤9.9

82 years

≤8.7

≤9.9

83 years

≤8.7

≤9.9

84 years

≤8.7

≤9.9

85 years

≤8.6

≤9.8

86 years

≤8.5

≤9.8

87 years

≤8.4

≤9.7

88 years

≤8.3

≤9.7

89 years

≤8.1

≤9.5

90 years

≤7.9

≤9.4

91 years

≤7.6

≤9.2

92 years

≤7.4

≤9.0

93 years

≤7.1

≤8.8

94 years

≤7.0

≤8.7

= 95 years

≤6.9

≤8.6

 

For SI unit Reference Values, see www.mayocliniclabs.com/order-tests/si-unit-conversion.html

Day(s) Performed

Monday through Friday

CPT Code Information

83497

LOINC Code Information

Test ID Test Order Name Order LOINC Value
HIAA 5-Hydroxyindoleacetic Acid, U 1695-6

 

Result ID Test Result Name Result LOINC Value
9248 5-Hydroxyindoleacetic Acid, U 1695-6
TM35 Collection Duration 13362-9
VL33 Urine Volume 3167-4

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

Report Available

2 to 4 days

Urine Preservative Collection Options

Note: The addition of preservative must occur prior to beginning the collection.

Ambient (no additive)

No

Refrigerate (no additive)

OK

Frozen (no additive)

OK

50% Acetic Acid

Preferred

Boric Acid

OK

Diazolidinyl Urea

No

6M Hydrochloric Acid

OK

6M Nitric Acid

OK

Sodium Carbonate

OK

Thymol

OK

Toluene

OK

Forms

If not ordering electronically, complete, print, and send an Oncology Test Request (T729) with the specimen.