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Test Code ADIC Disseminated Intravascular Coagulation/Intravascular Coagulation and Fibrinolysis (DIC/ICF) Profile, Plasma


Ordering Guidance


This profile will not detect all bleeding disorders, such as von Willebrand disease. For patients with amyloidosis and bleeding symptoms, obtaining a limited bleeding diathesis profile is suggested.

 

Multiple coagulation profile tests are available. See Coagulation Profile Comparison for testing that is performed with each profile.



Shipping Instructions


Send the 5 aliquot tubes in the same shipping container.



Necessary Information


 



Specimen Required


Specimen Type: Platelet-poor plasma

Patient Preparation: Patient should not be receiving Coumadin or heparin. If so, note on request.

Collection Container/Tube: Light-blue top (3.2% sodium citrate)

Submission Container/Tube: 5 Plastic vials

Specimen Volume: 5 mL in 5 plastic vials, each containing 1 mL

Collection Instructions:

1. For complete instructions, see Coagulation Guidelines for Specimen Handling and Processing.

2. Centrifuge, transfer all plasma into a plastic vial, and centrifuge plasma again.

3. Aliquot plasma (1 mL per aliquot) into 5 separate plastic vials, leaving 0.25 mL in the bottom of centrifuged vial.

4. Freeze plasma immediately (no longer than 4 hours after collection) at -20° C or, ideally -40° C or below.

Additional Information: Double-centrifuged specimen is critical for accurate results as platelet contamination may cause spurious results.


Forms

1. Coagulation Patient Information (T675)

2. If not ordering electronically, complete, print, and send a Coagulation Test Request (T753) with the specimen.

Useful For

Establishing laboratory evidence of disseminated intravascular coagulation

Profile Information

Test ID Reporting Name Available Separately Always Performed
ADICI DIC/ICF Prof Interpretation No Yes
APTSC Activated Partial Thrombopl Time, P Yes, (order APTTP) Yes
TTSC Thrombin Time (Bovine), P Yes Yes
CLFIB Fibrinogen, Clauss, P Yes, (order FIBTP) Yes
DIMER D-Dimer, P Yes, (order DDITT) Yes
PTSC Prothrombin Time (PT), P Yes, (order PTTP) Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
RTSC Reptilase Time, P Yes No
DRV1 Dilute Russells Viper Venom Time, P Yes, (order DRVI1) No
PNP Platelet Neutralization Procedure No No
PTMSC PT Mix 1:1 No No
APMSC APTT Mix 1:1 No No
DRV2 DRVVT Mix No No
DRV3 DRVVT Confirmation No No
F_2 Coag Factor II Assay, P Yes No
FACTV Coag Factor V Assay, P Yes No
F_7 Coag Factor VII Assay, P Yes No
F8A Coag Factor VIII Activity Assay, P Yes No
F_9 Coag Factor IX Assay, P No No
F_10 Coag Factor X Assay, P Yes No
F_11 Coag Factor XI Assay, P Yes No
F_12 Coag Factor XII Assay, P Yes No
PTFIB PT-Fibrinogen, P Yes No
SOLFM Soluble Fibrin Monomer No No
HEXLA HEX LA, P No No

Testing Algorithm

Initial testing includes prothrombin time (PT), activated partial thromboplastin time (aPTT), thrombin time (TT), fibrinogen, D-dimer, and disseminated intravascular coagulation/intravascular coagulation and fibrinolysis (DIC/ICF) profile interpretation.

 

If PT is greater than 13.9 seconds, then PT mix will be performed at an additional charge.

 

If aPTT is 38 seconds or more, then aPTT mix and dilute Russell's viper venom time (dRVVT) will be performed at an additional charge.

 

If dRVVT ratio is 1.20 or more, then dRVVT mix and dRVVT confirmation will be performed at an additional charge.

 

If fibrinogen is less than 150 mg/dL, or clinically indicated, then PT-fibrinogen will be performed at an additional charge.

 

If D-dimer is greater than 500 ng/mL fibrinogen equivalent units, then soluble fibrin monomer will be performed at an additional charge.

 

If aPTT mix is 38 or more seconds and TT is less than 35.0 seconds (no evidence of heparin), then platelet neutralization procedure will be performed at an additional charge.

 

If TT is 25.0 or more seconds, then reptilase time will be performed at an additional charge.

Method Name

PTSC, APTSC, TTSC: Optical Clot-Based

CLFIB: Clauss

DIMER: Latex Immunoassay (LIA)

ADICI: Medical Interpretation

Reporting Name

DIC/ICF Prof

Specimen Type

Plasma Na Cit

Specimen Minimum Volume

See Specimen Required

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma Na Cit Frozen 14 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Reference Values

An interpretive report is provided.

Day(s) Performed

Monday through Friday

Report Available

1 to 7 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

See Individual Test IDs

CPT Code Information

85610-PTSC

85730-APTSC

85670-TTSC

85379-DIMER

85384-CLFIB

85390-26-ADICI

85210-Factor II (if appropriate)

85220-Factor V (if appropriate)

85230-Factor VII (if appropriate)

85240-Coagulation factor VIII assay (if appropriate)

85250-Factor IX (if appropriate)

85260-Factor X (if appropriate)

85270-Factor XI (if appropriate)

85280-Factor XII (if appropriate)

85366-Soluble fibrin monomer (if appropriate)

85385-PT-Fibrinogen (if appropriate)

85597-Platelet neutralization for lupus inhibitor (if appropriate)

85598-Hex LA (if appropriate)

85611-PT mix 1:1 (if appropriate)

85613-DRVVT (if appropriate)

85613-DRVVT mix (if appropriate)

85613-DRVVT confirm (if appropriate)

85635-Reptilase time (if appropriate)

85732-APTT mix 1:1 (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
ADIC DIC/ICF Prof 98125-8

 

Result ID Test Result Name Result LOINC Value
CLFIB Fibrinogen, Clauss, P 48664-7
TTSC Thrombin Time (Bovine), P 46717-5
603323 Reviewed by 18771-6
DIMER D-Dimer, P 48067-3
APTSC Activated Partial Thrombopl Time, P 14979-9
PTSEC Prothrombin Time (PT), P 5902-2
INRSC INR 6301-6
603182 DIC/ICF Prof Interpretation 69049-5